PhosphoLean® N-Oleoyl-PE + EGCG (NOPE + EGCG) is the "next generation" nutritional supplement compound for advanced appetite control and weight management. PhosphoLean® NOPE + EGCG is a safe, natural, and effective nutritional supplement compound that can help individuals manage their ideal body weight.
Overweightness and obesity are increasing at alarming rates, and seemingly in all age groups except, perhaps, the elderly. The toll that obesity, in particular, places on us from both family and social standpoints is far reaching, especially considering management of health costs and overall illness commonly associated with obesity.
Recent research involving the manipulation of appetite has shown that suppressing appetite and thus reducing the intake of food is an effective means to controlling both energy balance and body weight. Since appetite suppression is a major controlling point for energy (food) intake, managing appetite is crucial in controlling healthy body weight, especially when combined with health conscious lifestyle choices that include attention to proper food intake, dietary supplementation, and exercise.
Under the severe stress levels experienced during dieting, studies have shown that PhosphoLean® NOPE + EGCG can effectively help individuals manage the daily stress of their calorie reduced diets and help them stay on diets for longer periods of time. Only this will lead to long-term diet success.
- Health Benefits
- Helps individuals stay on their stressful low calorie diets to achieve weight loss goals.
- Fights "Diet Dropout".
- Suppresses appetite so food and calorie intake can be reduced.
- Reduces diet stress and minimizes depression, that is normally felt when dieting.
- Reduces binge eating and between meal eating.
- Improves insulin resistance and overall physiology.
- Science Information
PhosphoLean® N-Oleoyl-PE + EGCG (NOPE + EGCG) is a proprietary phosphobioflavonic complex of N-oleoyl-phosphatidyl-ethanolamine (NOPE), which contains oleoyl ethanolamine (OEA) bound to phosphatidylethanolamine (PE), a naturally occurring phospholipid found in animal and vegetable foods, and epigallocatechin gallate (EGCG), from standardized green tea extract.
After oral administration, PhosphoLean® NOPE + EGCG is gastro-protected in the stomach, and in the intestinal tract, OEA, a newly discovered lipid mediator involved in the regulation of feeding, is enzymatically liberated.
Recent research has shown that OEA binds to a cell receptor class called peroxisome-proliferator-activated receptor-alpha (PPAR-alpha) found in the intestinal tract. These receptors, when activated, are responsible for signaling the brain center to decrease appetite and hence to reduce both food intake and body weight gain.
Recent findings from a large study involving 138 obese and overweight men and women on an eight week low calorie diet, conducted by Dr. Mariangela Rondanelli at the University of Pavia in Italy, showed that subjects on PhosphoLean® NOPE + EGCG experienced only a 6% drop out rate vs. a 27% drop put rate for the placebo group.
In addition, sensation of appetite, depressive symptoms, and binge eating severity scores were statistically much more favorable for the PhosphoLean® NOPE + EGCG group. Finally, insulin resistance and blood lipid markers were also statistically more favorable for this active group as well.
There is an increasing demand for pharmaceutical treatment for overweightness and obesity - lifestyle-associated conditions. Decreasing nutrient absorption, inhibition of appetite, and increasing thermogenesis are all currently being considered as possible pharmacological methods of treatment, while appetite suppression, through discovery of special nutrients and newly discovered metabolic pathways, is now opening new science doors.
The EGCG polyphenols in PhosphoLean® NOPE + EGCG act synergistically with OEA via sympathetic activation of thermogenesis and increased fat oxidation, thus enhancing its weight management effects.
- Applications
- Dietary supplements.
- Functional foods.
- Functional beverages.
- Medical foods.
The ingredient compound PhosphoLean® N-Oleoyl-PE + EGCG (NOPE + EGCG) has particular application in weight management and in men's and women's healthy lifestyle supplement products. The scientific support for the cell-signaling mechanism of PhosphoLean® NOPE + EGCG to "turn off the hunger switch" is well acknowledged and clinical work in this arena is ongoing. Based on continued trends in society, the future for PhosphoLean® NOPE + EGCG in weight management formulations looks very, very bright.
