PhosphoLean™ N-Oleoyl-PE + EGCG is a proprietary phosphobioflavonic complex of N-oleoyl phosphatidylethanolamine (NOPE), which contains oleoyl ethanolamine
(OEA) bound to phosphatidylethanolamine (PE), a naturally
occurring phospholipid found in animal and vegetable foods, and epigallocatechin gallate (EGCG), from standardized green tea extract. PhosphoLean™ N-Oleoyl-PE + EGCG operates via novel cell signaling,
through a cell receptor class called peroxisome- proliferator-activated receptor-alpha (PPAR-) found in the intestinal tract. These receptors, when activated, are responsible for signaling the brain center to decrease appetite and hence to reduce food intake and body weight gain.
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OVERWEIGHTNESS, OBESITY & LIFESTYLE… |
 Overweightness and obesity are increasing at alarming rates, and seemingly in all age groups except, perhaps, the elderly. The toll that obesity, in particular, places on us from both family and social standpoints is far reaching, especially considering management of health costs and overall illness commonly associated with obesity. There is an increasing demand for pharmaceutical treatment of this lifestyleassociated condition. Decreasing nutrient absorption, inhibition of appetite, and increasing thermogenesis are all currently being considered as possible pharmacological methods of treatment, while appetite suppression, through discovery of special nutrients and newly discovered metabolic pathways, is opening new science doors.
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APPETITE SUPPRESSION & WEIGHT MANAGEMENT… |
Recent research involving the manipulation of appetite has shown that suppressing appetite and thus reducing the intake of food is an effective means to controlling both energy balance and body weight. Since appetite suppression is a major controlling point for energy (food) intake, managing appetite is one of the most important components to help control healthy body weight, especially when combined with health conscious lifestyle choices that include attention to proper food intake and exercise.
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THE SCIENCE BEHIND PHOSPHOLEAN™ N-OLEOYL-PE + EGCG… |
PhosphoLean™ N-Oleoyl-PE + EGCG is a proprietary phosphobioflavonic complex of N-oleoyl-phosphatidyl-ethanolamine
(NOPE), which contains oleoyl ethanolamine (OEA) bound to phosphatidylethanolamine (PE), a naturally occurring phospholipid found in animal and vegetable foods, and epigallocatechin gallate (EGCG), from standardized green tea extract. PhosphoLean™ N-Oleoyl-PE + EGCG is the “next generation” nutritional supplement compound for advanced
appetite control, and safe and effective weight management.
The EGCG polyphenols in PhosphoLean™ N-Oleoyl-PE + EGCG act synergistically with OEA via sympathetic activation of thermogenesis and increased fat oxidation, thus enhancing the weight management effects of PhosphoLean™ N-Oleoyl-PE + EGCG markedly. PhosphoLean™ N-Oleoyl-PE + EGCG is a safe, natural, and very effective nutritional supplement compound to help manage healthy body weight, especially when combined with healthy lifestyle choices that include proper nutrition management and exercise.
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CELL SIGNALING & SWITCHING OFF FEEDING SIGNALS… |
After oral administration, PhosphoLean™ N-Oleoyl-PE + EGCG is gastro-protected in the stomach, and in the intestinal tract, oleoyl ethanolamine (OEA), a newly discovered lipid mediator involved in the regulation of feeding, is enzymatically
liberated. The result is decreased appetite, which leads to reduced food intake and finally to reduced body weight gain.
Recent research has shown that OEA binds to a cell receptor class called peroxisomeproliferator- activated receptor-alpha
(PPAR-) found in the intestinal tract. These receptors, when activated, are responsible for signaling the brain center to decrease appetite and hence to reduce food intake and body weight gain.
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HANDLING THE STRESS DURING DIETING… |
 Under the severe stress levels experienced during dieting, studies have shown that PhosphoLean™ N-Oleoyl-PE + EGCG can effectively help individuals manage the daily stress of their calorie reduced diets and help them stay on diets for longer periods of time. PhosphoLean™ N-Oleoyl-PE + EGCG can be an important component in cutting-edge weight management formulations, and canhelp make dieting more successful, especially when combined with proper nutrition
and adequate exercise.
Chemi Nutra
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If you require product samples for evaluation, technical applications assistance, supporting scientific information, or information on pricing and product availability, please contact us directly. We would be pleased to assist you in your product development and positioning needs for your value-added nutritional supplements.
TALK TO THE EXPERTS…
We look forward to sharing our expertise with you.
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